Social Inequality and Mobilization in Changing Thailand

Inequality has long persisted in Thailand and its level reached a peak in 2018. Around the end of 2019, the Covid-19 pandemic began to spread around the world and reached Thailand in January 2020, intensifying inequality with critical socio-economic disruptions. Subsequently, over 2,000 protests took place from 2020 to 2022. The combination of challenges caused rapid changes in Thailand. This article offers explanations of ‘who' was doing ‘what' and ‘how' in response to inequality. The article discusses situations of social inequality and people's reactions during the period 2019-2022, by using Bourdieu's concept of capital to tackle inequality and the demands of the various groups. The article utilized a quantitative method based on measures of frequency and regression techniques. The results demonstrate that the middle classes want democracy, and the working classes want more equality and participation. Key responses to social inequality and the government administration included both online and onsite mobilizations. Findings show that age, residency, and capital have impacts on mobilizations in which young people constitute the largest group to join both physical and virtual spaces. © The Authors.

Development of warm autoimmune hemolytic anemia after initiation of Ruxolitinib in a patient with STAT1 gain-of-function mutation

Introduction: STAT1 gain-of-function (GOF) disease is associated with chronic mucocutaneous candidiasis (CMC) and a broad spectrum of infectious, inflammatory, and vascular manifestations. The Janus Kinase inhibitor ruxolitinib has been used successfully for CMC and autoimmune phenomena. We describe a case of warm autoimmune hemolytic anemia (WAIHA) in a patient with STAT1 GOF disease after initiating ruxolitinib. Case report: A 36-year-old man with STAT1 c.850G>A (p.Glu284Lys) mutation presented with CMC as well as recurrent viral and bacterial infections, lymphadenopathy, enteritis, nodular regenerative hyperplasia (NRH) and splenomegaly. Immune workup confirmed a combined immunodeficiency with hypogammaglobulinemia and T-cell lymphopenia. Ruxolitinib was initiated at 5 mg twice daily (due to pre-existing thrombocytopenia) with up titration over 3 months to 20 mg twice daily. He improved with weight gain, increased energy, resolution of chronic anemia, and improved lymphadenopathy and splenomegaly on imaging. Serum CXCL9 only minimally decreased from 4660 pg/ml to 3990 pg/ml. Soon after reaching ruxolitinib 20 mg twice daily, he developed JC viremia, prompting dose reduction to 15 mg BID. Within two weeks, he developed a non-COVID upper respiratory tract infection followed by fatigue, shortness of breath with ambulation, and dark urine. Emergency evaluation revealed warm antibody positive hemolytic anemia with a hemoglobin of 5 g/dL, and worsened thrombocytopenia. He was treated with blood transfusions, pulse steroids, and high-dose IVIG with stabilization but continued hemolysis. Due to the JC viremia, there was concern to give rituximab with increased PML risk. Bone marrow showed trilineage hematopoiesis, a mild increase in megakaryocytes and RBC precursors, and a loss of B-cell progenitors with retention of mature B cells. His B and T lymphocyte numbers had increased since prior to ruxolitinib, with a predominance of Tfh1-cells (58.7% of total Tfh-cells). He was started on sirolimus with a slow taper of prednisone with continued stable hemoglobin and platelets, and resolution of hemolysis after 3 months. Conclusion(s): To our knowledge, this is the first case of a STAT1 GOF patient developing WAIHA while receiving ruxolitinib therapy. Treatment choices were complicated by the risks of PML. Sirolimus combined with ruxolitinib allowed wean of corticosteroid and subsequent resolution of hemolysis.Copyright © 2023 Elsevier Inc.

Successful ECMO course in an Acquired Immune Deficiency Syndrome (AIDS) patient with ARDS complicated by pneumocystis jirovecii pneumonia and COVID-19: A unique case

Objectives: Reviewing current literature and case reports of patients placed on Venous-Venous ECMO support for HIV and AIDS, with confection with Pneumocystis pneumonia and covid-19 pneumonia. The use of extracorporeal membrane oxygenation (ECMO) in patients who have acute respiratory distress syndrome has been shown to have very good outcomes. However, there is limited data to support the initiation of ECMO in patients who have human immunodeficiency virus infection with or without acquired immune deficiency syndrome. Method(s): We present a unique and challenging case of a 30 year old male, with no known past medical history, unvaccinated against covid-19, who presented with one week of progressive shortness of breath. On admission he was found with moderate bilateral infiltrates and was diagnosed with covid-19 pneumonia. Despite appropriate medical therapy, patient developed worsening hypoxic respiratory failure. Found to have elevated (1- 3)-7beta;-d-glucan and tested positive for HIV. CD4 count 11, HIV viral load 70,000. The patient remained severely hypoxemic despite mechanical ventilation, sedation, paralytics and proning. Venous venous extracorporeal membrane oxygenation was initiated. Considering his non improvement with variety of antivirals and antibiotics and with elevated (1-3)-7beta;-d-glucan in the setting of AIDS he was treated for presumed Pneumocystis pneumonia. The patient tolerated proning while on VV ECMO and his course was complicated with bilateral pneumothorax necessitating chest tube placement. Result(s): The patient successfully completed 64 days on VV ECMO, where he was treated for PCP pneumonia, covid pneumonia, CMV viremia and tolerated initiation of anti-retroviral therapy. Patient was successfully decannulated, and ultimately discharged from the hospital. Conclusion(s): VV-ECMO can be a beneficial intervention with successful outcomes in severely immunocomprimised patients with AIDS. This case highlights the importance of minimizing sedation and early mobilization on ECMO support. (Figure Presented).

Ups and Downs of Business Activity in the Waves of Crises, the Coronavirus Pandemic and Unprecedented Western Sanctions

Subject of article - the dynamics of the integrated Business Activity Index of the Institute of Economics of the Russian Academy of Sciences in 10 main areas of the national economy and the Index of output of goods and services by basic types of economic activity of Rosstat (Rosstat Index) from 2018 to July 2022 inclusive. Growth factors and a list of key macro indicators that determine the level of business activity in the relevant sectors of the economy, as well as the results of calculating the weights of these sectors, are considered. The aim of the article is to substantiate the advantages of the methodology for constructing the IE RAS Index, which includes development indicators of 10 areas of the national economy, in comparison with the Rosstat Index. Theoretical studies are based on practical calculations performed on the basis of official statistical reporting, and a comparative analysis of the results with the dynamics of the Rosstat Index. Research period: post-crisis 2018-2019, pandemic and post-pandemic 2020-2021 and initial stage of the mobilization period for the economy- January-July 2022. To calculate the IE RAS Index, the method of construction of integral estimates of macroeconomic dynamics, correlation analysis, as well as a matrix of coefficients of pair correlation for determination of index weights are used, which is a convincing justification of scientific novelty of the proposed methodology of construction and practical use of the IE RAS Index. Based on a comparative analysis of the dynamics of the indices, it was found that the maximum drop in the IE RAS Index and the Rosstat Index was observed in 2020, and the maximum growth was observed in the post-pandemic 2021. Moreover, according to the IE RAS methodology, larger parameters and earlier dates for the start of decline and growth of business activity in comparison with the Rosstat Index were recorded. As a result, new convincing evidence of the advantages of the IE RAS Index was obtained, the main of which is a more reliable and accurate determination of the critical moments of a change in the business activity trend and, accordingly, the timing of the onset and overcoming of crisis processes in socio-economic development. The authors conclude that, in the new geopolitical reality, it is necessary to include the IE RAS Index as a target indicator for the country's ability to secure state sovereignty. © Frenkel A. A., Tikhomirov B. I., Surkov A. A., 2023 .

Resource Support for "Mobilization-Participation" in Public Health Emergencies Based on a Complex Network Evolutionary Game.

The organized system of emergency resources with the participation of social subjects features a network, which puts forward new requirements for mobilization policies for public health emergencies. Considering the "mobilization-participation" action of the relationship between the government and social resource subjects and revealing the mechanism of governance measures represent the foundation of developing effective mobilization strategies. To analyze the behavior of subjects in an emergency resource network, this study proposes a framework for the emergency actions of government and social resource subjects, as well as clarifies the functions of relational mechanisms and interorganizational learning in decision making. The game model and its rules of evolution in the network were developed by considering the interventions of rewards and penalties. An emergency resource network was constructed on the basis of a response to the COVID-19 epidemic in a city in China, and a simulation of the "mobilization-participation" game was designed and conducted. We propose a path to promote emergency resource actions by analyzing the initial situations and the interventions' effects. This article suggests that guiding and improving the initial selection of subjects under a certain reward system would be an effective path to facilitate resource support actions during public health emergencies.

Thoracic Mobilization and Respiratory Muscle Endurance Training Improve Diaphragm Thickness and Respiratory Function in Patients with a History of COVID-19.

Background and Objectives: Common problems in people with COVID-19 include decreased respiratory strength and function. We investigated the effects of thoracic mobilization and respiratory muscle endurance training (TMRT) and lower limb ergometer (LE) training on diaphragm thickness and respiratory function in patients with a history of COVID-19. Materials and Methods: In total, 30 patients were randomly divided into a TMRT training group and an LE training group. The TMRT group performed thoracic mobilization and respiratory muscle endurance training for 30 min three times a week for 8 weeks. The LE group performed lower limb ergometer training for 30 min three times a week for 8 weeks. The participants' diaphragm thickness was measured via rehabilitative ultrasound image (RUSI) and a respiratory function test was conducted using a MicroQuark spirometer. These parameters were measured before the intervention and 8 weeks after the intervention. Results: There was a significant difference (p < 0.05) between the results obtained before and after training in both groups. Right diaphragm thickness at rest, diaphragm thickness during contraction, and respiratory function were significantly more improved in the TMRT group than in the LE group (p < 0.05). Conclusions: In this study, we confirmed the effects of TMRT training on diaphragm thickness and respiratory function in patients with a history of COVID-19.

[The effect of rehabilitation and one year follow-up for a COVID-19 patient on prolonged mechanical ventilation].

We herein report the outcomes of rehabilitation intervention for a patient in his 80s with chronic obstructive pulmonary disease on prolonged mechanical ventilation after COVID-19 infection. The patient was forced to be long-term bedridden due to respirator dependence, showing notable muscle weakness and needing full assistance for all of his activities of daily living (ADL). We implemented rehabilitation for the purposes of withdrawal from mechanical ventilation and improvement of his physical function. We provided a combination program of range of motion exercise, resistance training, and gradual mobilization, such as sitting on the edge of the bed, moving between the bed and wheelchair, sitting on the wheelchair, standing and walking. After rehabilitation for 24 days, the patient was withdrawn from mechanical ventilation, his muscle strength recovered to a level of 4 (Good) on manual muscle testing (MMT) and he became able to walk using a walker. A follow-up survey one year later confirmed that he performed ADL without assistance and returned to work.

The Impact of COVID-19, Election Policies, and Partisanship on Voter Participation in the 2020 U.S. Election

The COVID-19 pandemic had the potential to wreak havoc on elections. Democracies initiated varied policies to minimize health risks to voters and election workers. This study assesses the impact of voting policies, personal exposure to COVID, and partisanship on voter behavior in the 2020 U.S. general election. Using a comparative state-politics approach and new data, we demonstrate that exposure to COVID substantially influenced voter turnout, and election policies had a major effect on whether a voter cast a ballot by mail, early in-person, or in-person on Election Day. Unique circumstances, including the emergence of voting policies as a polarizing issue, also spawned a new partisan voting gap that is especially prominent among heavy news consumers. Compared to 2018, many more Democrats than Republicans abandoned Election Day voting in favor of mail voting.

Fighting Covid-19 in rural communities: coordinated mobilization and reconstruction of community order in a village in Northern China

Taking a remote village in Inner Mongolia Autonomous Region as a case study, this paper discusses how coordinated mobilization constructed a temporary grassroots-level emergency order in response to the Covid-19 pandemic. The study reveals that the temporary emergency order was established through a combination of state power, villagers' understanding of the infection risks of the coronavirus, and village self-management traditions. It finds that party members, elites, and villagers made a coordinated effort to mobilize and fight Covid-19. The paper concludes the state can effectively mobilize loosely-knit rural communities to face major risks such as the Covid-19 pandemic.

The political field of the youths in Colombia in time of pandemic

This investigation has as main objective to describe to the political field of the youths of Colombia in times of the pandemic of the Covid-19, based on the social-legal study of the issue of the omission of the youths as political subjects for part of the legislator and the executive, in the decision making of general interest that directly affects them during the states of exception and that demonstrate faults of the political representation and the abuse of the administrative power in the management of the adopted measures in this conjuncture. The investigation apply a qualitative, reflexive, and of socio-legal carácter, through which it defends that the recognize of the youths as politics sujets and their paper in the politic are a social field in dispute. In the perspective of Pierre Bourdieu, the youths are excluded of the politic. In this orden, exist a reproduction of the inequality between adults and youths as also between the same youths. The originals results of this research allows to demonstrate the thesis bourdiana in the colombian case. In this sense, the investigation concludes that low the exceptional juvenile legal system impost with the exception state during the pandemic, the political treatment of the youths have been given of form vertical, universal and homogenizing with base in the absolute power of police of the state;while low this oppressor regimen exist a rule of the political structural inequiality. © 2022 Centro Universitario de Brasilia. All rights reserved.

Rehabilitation

Many patients hospitalized due to COVID-19 presented with varying degrees of impairments and disabilities mostly attributed to prolonged ICU stay. The consequences of severe respiratory illness and longer duration of ICU stay can lead to long-term physical, emotional, and cognitive dysfunction. The rehabilitation department at SBH Health System had its own set of challenges and had to quickly adapt to constant changes and needs of the patients. This chapter focuses on the important role of rehabilitation in pandemic response, restoring function, and recovery of COVID-19 survivors. It outlines the effectiveness of prone positioning and early mobilization that can make a significant difference in the patients' long-term quality of life. The integrated approach to discharge planning with multidisciplinary involvement facilitated a smooth transition from the hospital to their home. This helped as demands for post-acute care needs increased whether it was skilled nursing facilities for short-term rehabilitation, home care services, or outpatient services, including virtual rehabilitation or telehealth. © SBH Health System 2022.

State and main directions of modernization of infectious health service of the Russian Federation

In article are considered the indicators reflecting a condition of infectious health service of the Russian Federation are offered the main directions it to modernization as parts the uniform state system of prevention and actions in emergency situations, including in the conditions of a pandemic of infectious diseases, author's definitions of medical mobilization, mobilization preparation and readiness of the territory are given.Copyright © 2021 Nutritec. All rights reserved.

Sending Money Home in Conflict Settings: Revisiting Migrant Remittances

Despite the challenges, remittances frequently remain a primary source of economic support for those left behind, as well as for national development of post-conflict countries. [...]situations in the wake of recent conflicts are known for heightened remittance flows.3 As a large share of the remittance flows in conflict settings occurs through informal channels, the importance of remittances in these economies has often been underestimated. A focus on broader settings that can provide security, justice, and economic sustenance to individuals and communities affected by the crisis has been reflected in the human security approach6 to post-conflict7 development.8 Remittances can be central to fighting poverty—by diversifying household income sources, providing capital for productive investment and facilitating local markets, and funding education, health, and other social expenses.9 Remittances can contribute to post-conflict recovery in the long term. "20 Horst has shown that among the Somali diaspora in Norway, most political engagements do not occur through state institutions but take place on sub-national levels, including individual and group money transfers and certain humanitarian initiatives.21 Somali diaspora members mediate with clan leaders and elders who can contribute to reconciliation processes through customary mechanisms such as compensatory payments, but as noted above, such involvement can also sustain continued warfare.22 While the role of diaspora in post-conflict reconstruction efforts can be significant, diaspora can also remain an "under-utilized resource" whose strong emotional connection to their home country is offset by unstable institutional environments.23 Weak formal institutions and regulatory frameworks may offer little systematic support for entrepreneurship development, which is constrained by high transaction and compliance costs. Informal institutions and cultural attitudes remain important in the post-conflict assimilation of returning migrants who bring with them beliefs and understandings from their countries of settlement, resulting in hybrid norms and institutions.24 Many forcibly displaced and returning migrants may also lack properly transferable professional skills.25 The transfer of social and political remittances does not always signify "diffusion of democracy"—the effects of returning migrants to democratization depend on their experience of political mobilization as migrant workers, as well as on the status of democratic values in the political order of the host country, among other factors.26 Changing perspectives on conflict-affected remittances Remittances became central in the migration scholarship only in the 1990s, when the analytical focus shifted from migration as a result of [End Page 44] decision-making of rational individuals towards a more nuanced view of the role of households, social networks, and community in migration processes.

One-year outcomes following rehabilitation for chronic hip-related groin pain: ancillary analysis of a pilot randomized clinical trial

Purpose: Rehabilitation to address modifiable factors associated with chronic hip-related groin pain (CHRGP) may lead to reduced pain and improved function, yet little is known about its effectiveness. We assessed the preliminary effects of two interventions that target two distinct mechanisms, sensory disturbances and abnormal movement patterns. Sensory disturbances such as peripheral and central sensitization may contribute to pain persistence long after initial injury. Joint mobilization (JtMob) may impart a neurophysiological response within the nervous system that results in pain reduction and improved mobility. Abnormal movement patterns may create altered mechanical stresses on hip joint structures, resulting in pain and activity limitations. Movement pattern training (MoveTrain) may improve movement patterns and thus patient function. Method(s): Patients with CHRGP, 18-40, were enrolled. Assessments included self-report questionnaires, clinical exam, and quantitative sensory testing. Outcomes included the Hip disability and Osteoarthritis Outcome Score (HOOS), a patient-reported outcome;frontal plane kinematics of hip, pelvis, and trunk during single leg squat;and pain pressure threshold (PPT) assessed at the anterior groin of the most bothersome hip and dominant thenar eminence (local and generalized pressure hypersensitivity, respectively). Patients were randomized to JtMob or MoveTrain in a 1:1 ratio stratified by sex and HOOS Symptoms. Treatment for both groups included 10 individualized visits over 12 weeks with a trained physical therapist (PT);assessment of patient goals and education which focused on patient-specific tasks reported by the patient to be symptom-producing;instruction in a home exercise program (HEP);and handouts that provided education, description and benefits of assigned treatment and instructions for HEP. The key element of JtMob was PT-provided manual techniques using specific criteria to determine the joint mobilization techniques and parameters used for each patient. The patient's symptom report to each technique was monitored and if indicated, the technique modified according to our outlined procedures. The HEP included flexibility exercises. The key element of MoveTrain was task-specific instruction to correct abnormal movement patterns displayed during daily and patient-specific tasks. For example, hip adduction was minimized during a step descent. The HEP included repeated practice of modified tasks. Task difficulty was progressed based on each patient's performance. Immediately after treatment completion, patients returned for follow up assessment. To assess treatment sustainability after the active treatment phase, we collected HOOS at 6 and 12 months (extended follow-up), and kinematics and PPT at 12 months. Data from patients who provided any data after baseline were analyzed with a repeated measures analysis of variance (RM-ANOVA) with baseline value as a covariate, patient as a random effect, and an autoregressive covariance structure. After adjusting for baseline, the between-group difference in change from post-treatment to each extended follow-up results from pre-planned statistical contrasts in a RM-ANOVA that includes main effects for treatment group, visit and the group by visit interaction. The within-group treatment effect at each extended follow-up was calculated by subtracting the earlier time point from the later follow-up within each treatment group. Dependent samples t-tests were used to assess the degree of within-group change. Result(s): Demographics and outcome data are provided in Tables 1 and 2, respectively. Thirty-three patients with CHRGP were randomized and 29 (88%) provided post-treatment data. Four patients did not complete treatment or post-treatment testing (3 due to COVID pandemic, 1 lost to follow up);6 patients did not complete 12 month laboratory testing (due to pandemic), but did complete 12 month questionnaires. Previously, we reported that both groups reported clinically important improvements in HOOS subscales and MoveTrain group improved hip and pelvis kinematics immediately after treatment compared to baseline. After adjusting for baseline, there were no between-group differences in change in outcomes between post-treatment and extended follow-up when comparing JtMob and MoveTrain, indicating that treatment effects immediately post-treatment were maintained at 12 months after treatment completion. Conclusion(s): Our preliminary findings suggest that 12 weeks of JtMob or MoveTrain, may result in improvements in patient-reported pain and function and these effects may persist 12 months after treatment completion. A future, larger trial to definitively assess the efficacy of JtMob and MoveTrain and identify factors associated with long-term outcomes will improve our ability to develop treatment strategies for people with CHRGP. [Formula presented] [Formula presented]Copyright © 2023

The irruption of the political after the pandemic: The case of Panama.

This article analyzes the emergence of new political agendas as a result of the social mobilization that took place in Panama during the pandemic and how these were finally translated into a new institution for the negotiation of public policies –The Single Roundtable for Dialogue (Mesa Única de Diálogo). Analytical narratives are used based on secondary sources. To this end, the literature and various indicators were examined and a newspaper search was conducted on the phenomenon studied. The hypothesis is that, although there have been previous protests in the Panamanian nation, there is a before and an after in relation to the one that occurred in July, 2022, in terms of the meaning and scope of the demands of mobilized actors. It was a moment of political irruption, in which those who do not usually have a voice demonstrated that they have one. This text characterizes the conditions of public policies in the Panamanian political system;describes the social and economic effects of COVID-19;and describes the process of political irruption and emergence of new agendas during the mobilization. The conclusions illustrate how the aforementioned protests constituted an interruption of the previous equilibrium of the country, where the notion of the public had been distorted and needed to be reformulated. (English) [ FROM AUTHOR] En este artículo se analiza la emergencia de nuevas agendas políticas producto de la movilización social ocurrida en Panamá durante la pandemia y cómo estas se tradujeron, finalmente, en una nueva institución para las negociaciones de las políticas públicas: la Mesa Única de Diálogo. Se emplean las narrativas analíticas basadas en fuentes secundarias;para ello se revisó la literatura y distintos indicadores y se realizó una búsqueda hemerográfica sobre el fenómeno estudiado. Como hipótesis se plantea que, si bien han ocurrido protestas previas en la nación panameña, existe un antes y un después en relación con la ocurrida durante julio de 2022 en términos del sentido y el alcance de las reivindicaciones de los actores movilizados: se trata de un momento de irrupción de lo político, en el cual quienes no suelen tener voz se manifiestan por tenerla. En el texto se caracterizan las condiciones en que se han dado las políticas públicas en el sistema político panameño, se describen los efectos sociales y económicos de la covid-19, así como el proceso de irrupción de lo político y la emergencia de nuevas agendas durante las movilizaciones. En las conclusiones se ilustra cómo las mencionadas protestas constituyen una interrupción de los equilibrios previos de un país, donde la noción de lo público ha estado deformada y requiere ser replanteada. (Spanish) [ FROM AUTHOR] Copyright of Íconos. Revista de Ciencias Sociales is the property of FLACSO Ecuador (Facultad Latinoamericana de Ciencias Sociales) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Mobilizing personal networks into concert audiences: The differential multilevel effects in an art convention

As a specific art convention, graduating music students in college often invite network members to attend their degree recitals. This customary practice of network mobilization involves two types of tie effects that seemingly conflicted with each other, which became more acute when the practice abruptly changed during the Covid-19 pandemic. Based on invitation and attendance records collected from seventy-one recitals in a span of two decades before (N = 4866) and during the pandemic (N = 428) in Taiwan, multilevel analysis helped untangle which concert and tie features contributed to successful invitations at both the recital and invitation levels. Recruiting a larger proportion of weak ties helped boost the overall attendance at the recital level, while strong ties ensured positive responses to individual invitations in terms of both meeting at the recital hall and recalling the recital, particularly before the pandemic. More importantly, certain cross-level effects changed during the pandemic while others remained intact.

A comparison of peripheral blood stem cell collection outcomes for multiple myeloma, mobilization matters in the era of IMiD induction

Collection of peripheral blood stem cells (PBSCs) for autologous stem cell transplant (ASCT) requires mobilization from the bone marrow. There is variation in mobilization choice;during the COVID-19 pandemic BSBMT&CT guidelines recommended using granulocyte-colony stimulating factor (G-CSF) alone to minimize the use of chemotherapy. We report on the impact of mobilization regimen on stem cell collection, and whether IMiD-containing induction therapy impacts on mobilization and consequently transplant engraftment times for 83 patients undergoing ASCT at Leeds Teaching Hospitals. Cyclophosphamide plus G-CSF (cyclo-G) mobilization yielded more CD34+ cells (8.94 vs. 4.88 x106/kg, p = < 0.0001) over fewer days (1.6 vs. 2.4 days, p = 0.007), and required fewer doses of salvage Plerixafor than G-CSF only (13.6% vs. 35%, p = 0.0407). IMiD-containing induction impaired all of these factors. CD34+ doses > 8x106/kg were more frequent with Cyclo-G (62% vs. 11%, p = 0.0001), including for those receiving IMiD 1st line induction (50% vs. 13.3%, p = 0.0381). Note that 92.6% of those receiving IMiD-free inductions were mobilized with Cyclo-G. The novel agents used in modern induction regimens (e.g Daratumumab) have been shown to impair yields, increasing the importance of optimizing mobilization regimens in the first instance. Furthermore, as cellular therapies become established in the management of multiple myeloma emerging data highlights the potential benefits of stem cell top up in the management of the haematological toxicities of these therapies. Our findings support re-adoption of Cyclo-G as the gold standard for mobilization to optimize PBSC harvesting and ensure sufficient cells for subsequent ASCTs.Copyright © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.

Documents on Democracy

Global/Canada The post–Cold War assumption of democracy's inevitable triumph—described by Francis Fukuyama as the "End of History" thesis—does not apply to our world, and democracies need to adjust accordingly, argues Canada's deputy prime minister, Chrystia Freeland. The jeers I face in Question Period, the fact-checking of skeptical journalists, the hard verdict of the ballot box—all of these make me a better minister than I would be if we governed in splendid authoritarian isolation. Support independent workers' power in and beyond these protests;abolish anti-worker practices like the 996 work schedule and strengthen labor law protections, including protecting workers' right to strike and self-organization, so they can participate more extensively in political life. Avoid the risky tactic of long-term occupation of streets and town squares—adopt "Be Water"-style mobilization to prevent authorities from too easily clamping down on protesters.

Year in Review 2022: Noteworthy Literature in Cardiothoracic Critical Care.

The past year in critical care medicine was notable for ongoing sequelae of the COVID-19 pandemic, including nationwide shortages and critical care demand in many regions in excess of usual operating capacity. Despite these challenges, evidence-based medicine and investigations into the optimal management of the critically ill continued to be at the forefront. This article is a collection of studies published in 2022 which are specifically relevant to cardiothoracic critical care. These noteworthy publications add to the existing literature across a broad spectrum of topics, from optimal timing of mechanical circulatory support (MCS), delirium prevention, updates in nutrition guidelines, alternative defibrillation techniques, novel ventilator management, and observing the downstream psychological impact of extracorporeal membrane oxygenation (ECMO) therapy.

Voices in the fields. Migrant farmworkers during COVID-19 in Spain and new forms of activism for dignity

The health crisis has revealed many of the structural and endemic problems that have existed in the agriculture sector in Spain over the last two decades: the high volume of foreigners in an irregular situation, the miserable informal settlements and substandard housing in which they are forced to "reside", and the extreme physical and social vulnerability of the workers, including those employed under official seasonal labor mobility schemes. These structural problems have traditionally been ignored by the administration, whose policies have focused on managing the mobility of migrants while neglecting the needs of migrant workers present in the territory. During the health crisis the emergence of the narrative on their "essential role", which was incorporated in the political discourse, together with the visibility of their poor working and living conditions, have generated, promoted or consolidated several struggles based on what we can call the right to live in dignity. In the Spanish case these struggles have been caused by three types of tensions that have become particularly intense during the Covid-19 pandemic: the tension between essentiality and disposability, between temporality and permanence, and between an active and a passive citizenship.